Cytisine

Cytisine is a naturally occurring alkaloid found in the seeds of the *Laburnum anagyroides* plant (Golden Rain tree). For decades, it has been used in Central and Eastern Europe as a smoking cessation aid. Its mechanism of action is similar to that of nicotine replacement therapies (NRTs)—it binds to nicotinic receptors in the brain, helping to alleviate withdrawal symptoms and reduce the urge to smoke. Clinical studies indicate that cytisine may improve quit rates compared to placebo, though its effectiveness relative to other cessation methods varies. Unlike prescription medications, cytisine is available in some regions as an over-the-counter supplement. However, it is not approved by the FDA in the U.S. Potential side effects may include mild nausea, dry mouth, or dizziness. It is not recommended for non-smokers, pregnant women, or individuals with certain medical conditions. For best results, cytisine should be used as part of a structured quit plan, including behavioral support. Always seek medical advice before starting any new supplement or cessation program.