Synephrine HCl (p-synephrine) is a bioactive compound found in citrus fruits, particularly bitter orange. It gained popularity as a substitute for ephedrine in weight management formulations due to its similar—but less potent—adrenergic activity. By interacting with adrenergic receptors, it may promote mild vasoconstriction, increased heart rate, and enhanced calorie expenditure. Studies indicate synephrine HCl could support metabolic rate and exercise performance without significantly impacting blood pressure in healthy individuals at recommended doses (typically 10–30 mg per serving). However, excessive intake or combining it with other stimulants (e.g., caffeine) may cause jitters or dizziness. Unlike synthetic fat burners, synephrine HCl is plant-derived and generally well-tolerated. It’s often included in pre-workout blends or thermogenic formulas. Note that it is not a magic pill—effective results require a balanced diet and regular exercise. Banned in some sports organizations, athletes should check compliance with their regulations. **Key Points:** • Derived from bitter orange, a natural source. • May support energy, focus, and metabolism. • Mild stimulant with a lower risk profile than ephedrine. • Not a substitute for medical treatment or healthy habits.